Table 1.
Characteristics of Analyzed Subjects in COPDGene and Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study
| COPDGene | ECLIPSE | |
|---|---|---|
| N | 4,558 | 1,741 |
| Age, yr | 65.5 (8.7) | 61.9 (7.9) |
| Sex, % female | 50 | 36 |
| Race, % African American | 27 | 0 |
| FEV1 % of predicted | 78.3 (24.9) | 55.0 (26.1) |
| FEV1/FVC | 0.67 (0.15) | 0.66 (0.21) |
| COPD, % GOLD 2–4 | 35 | 84 |
| Pack-years | 44.0 (24.0) | 45.4 (26.5) |
| Current smoking, % | 37 | 39 |
| BMI | 28.9 (6.3) | 26.6 (5.3) |
| Oral steroids, % | 2 | 0 |
| Inhaled steroids, % | 24 | 59 |
| Neutrophil, % | 59.4 (10.0) | 63.9 (8.2) |
| Neutrophil, 1,000 cells/μl | 4.3 (1.6) | 5.0 (1.6) |
| Lymphocyte, % | 29.4 (9.4) | 26.8 (7.6) |
| Lymphocyte, 1,000 cells/μl | 2.0 (0.7) | 2.0 (0.6) |
| Monocyte, % | 8.1 (2.4) | 6.2 (2.1) |
| Monocyte, 1,000 cells/μl | 0.6 (0.2) | 0.5 (0.2) |
| Eosinophil, % | 2.6 (1.7) | 2.8 (1.7) |
| Eosinophil, 1,000 cells/μl | 0.2 (0.1) | 0.2 (0.1) |
| Basophil, % | 0.6 (0.5) | 0.3 (0.2) |
| Basophil, 1,000 cells/μl | 0.03 (0.04) | 0.03 (0.02) |
Definition of abbreviations: BMI = body mass index; COPD = chronic obstructive pulmonary disease; ECLIPSE = Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; GOLD = Global Initiative for Obstructive Lung Disease.
Data are mean (SE) unless otherwise indicated.