Table 4.

Relationship of Cell Type Counts and Proportions at Baseline to 3-Year Change in Forced Expiratory Volume in 1 Second % of Predicted in 1,741 Smokers in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study

	Cell Type Count (1,000 Cells/μl)		Cell Type Proportion
	β	P Value	β	P Value
Neutrophils	−0.09 (0.12)	0.48	−0.05 (0.02)	0.031
Lymphocytes	0.63 (0.32)	0.05	0.07 (0.03)	0.008
Monocytes	−3.41 (1.08)	0.002	−0.32 (0.09)	0.001
Eosinophils	4.16 (1.43)	0.004	0.34 (0.11)	0.003
Basophils	−8.65 (12.8)	0.50	−0.50 (1.00)	0.62

Definition of abbreviations: β = change in forced expiratory volume in 1 second (FEV₁) over 3 years per unit change in cell count or proportion; COPD = chronic obstructive pulmonary disease.

Change in FEV₁, calculated as: last visit value − first visit value (i.e., negative values indicate decline in FEV₁). Models analyze one cell type at a time. All models are adjusted for FEV₁ % of predicted at baseline, number of days of follow-up, inhaled corticosteroid use at baseline, and smoking status at baseline and at last study visit.