Table 5.

Multivariate Models Relating Cell Type Counts and Proportions at Baseline to 3-Year Change in Forced Expiratory Volume in 1 Second % of Predicted in 1,741 Smokers in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study

	Neutrophil Count	Neutrophil %	Lymphocyte Count	Lymphocyte %	Monocyte Count	Monocyte %	Eosinophil Count	Eosinophil %
Cell proportions	—	1.03 (1.03)	—	1.11 (1.03)	—	0.69 (1.04)	—	1.43 (1.05)
Cell counts	0 (0.13)	—	0.76 (0.32)*	—	−4.64 (1.18)*	—	4.98 (1.46)*	—

Definition of abbreviation: COPD = chronic obstructive pulmonary disease.

^*P < 0.05.

Cell counts are in units of 1,000 cells/μl. Each row corresponds to a separate multivariate regression model. Models adjusted for baseline forced expiratory volume in 1 second % of predicted, number of days of follow-up, inhaled corticosteroid use at baseline, and current smoking status at baseline and last measurement.