Table 3.
Demographic characteristics at registration (safety set)
| Variable | Total | GHD | TS | CRF | SGA | ISS |
|---|---|---|---|---|---|---|
| No. of patients | 2,024 (100) | 1,297 (64.1) | 197 (9.7) | 9 (0.4) | 206 (10.2) | 315 (15.6) |
| Male | 1,048 (51.8) | 771 (59.4) | 0 (0) | 6 (66.7) | 104 (50.5) | 167 (53.0) |
| Female | 976 (48.2) | 526 (40.6) | 197 (100) | 3 (33.3) | 102 (49.5) | 148 (47.0) |
| Age (yr) | n=2,024 | n=1,297 | n=197 | n=9 | n=206 | n=315 |
| Median (range) | 8 (2–19) | 8 (2–19) | 9 (2–18) | 8 (2–15) | 6 (2–14) | 9 (2–16) |
| IQR | (5–11) | (5–11) | (5–11) | (2–13) | (5–9) | (6–11) |
| Age distribution (yr) | ||||||
| 0–5 | 573 (28.3) | 370 (28.5) | 51 (25.9) | 3 (33.3) | 80 (38.8) | 69 (21.9) |
| 6–10 | 938 (46.3) | 591 (45.6) | 87 (44.2) | 3 (33.3) | 105 (51.0) | 152 (48.3) |
| 11–15 | 501 (24.8) | 330 (25.4) | 54 (27.4) | 3 (33.3) | 21 (10.2) | 93 (29.5) |
| >15 | 12 (0.6) | 6 (0.5) | 5 (2.5) | 0 (0.0) | 0 (0.0) | 1 (0.3) |
| Height SDS | n=1,471 | n=922 | n=157 | n=8 | n=152 | n=232 |
| Median (range) | -2.26 (-6.97 to 6.23) | -2.25 (-6.97 to 6.23) | -2.58 (-6.34 to -0.66) | -2.43 (-3.54 to 0) | -2.23 (-5.14 to -0.18) | -2.17 (-5.31 to 1.54) |
| IQR | (-2.69 to -2.0) | (-2.64 to -2.01) | (-3.31 to -2.14) | (-3.26 to -1.72) | (-2.64 to -2.02) | (-2.61 to -1.85) |
| Weight SDS | n=1,484 | n=934 | n=160 | n=8 | n=151 | n=231 |
| Median (range) | -1.64 (-9.59 to 2.78) | -1.59 (-9.59 to 2.78) | -1.18 (-5.93 to 2.27) | -1.55 (-4.43 to -0.12) | -2.11 (-6.47 to 0.85) | -1.76 (-7.33 to 1.26) |
| IQR | (-2.36 to -0.91) | (-2.32 to -0.91) | (-2.09 to -0.33) | (-3.13 to -0.83) | (-2.78 to -1.57) | (-2.4 to -1.02) |
| BMI SDS | n=1,453 | n=915 | n=156 | n=8 | n=149 | n=225 |
| Median (range) | -0.27 (-16.88 to 3.47) | -0.23 (-16.88 to 2.88) | 0.51 (-1.92 to 3.47) | -0.89 (-2.89 to 1.61) | -0.81 (-5.6 to 2.09) | -0.58 (-4.6 to 2.69) |
| IQR | (-1.04 to 0.52) | (-0.98 to 0.53) | (-0.39 to 1.25) | (-1.72 to 0.51) | (-1.35 to -0.1) | (-1.29 to 0.14) |
| IGF-I SDS | n=1,601 | n=1,035 | n=146 | n=4 | n=158 | n=258 |
| Median (range) | -0.82 (-3.6 to 8.86) | -0.91 (-3.6 to 7.36) | -0.59 (-2.17 to 8.86) | -0.58 (-0.79 to -0.26) | -0.57 (-2.43 to 3.82) | -0.7 (-2.93 to 3.28) |
| IQR | (-1.29 to -0.32) | (-1.37 to -0.43) | (-1.12 to 0.1) | (-0.73 to -0.37) | (-1.08 to 0.04) | (-1.2 to -0.26) |
| BA (yr) | n=1,663 | n=1,072 | n=157 | n=7 | n=166 | n=261 |
| Median (range) | 6.8 (0.6–17) | 6 (0.6–17) | 8.5 (1–14) | 8.8 (1.5–13.5) | 5.5 (1.5–13.5) | 8.4 (2–15.6) |
| IQR | (4–9.5) | (3.5–9) | (5–10.8) | (2–12.6) | (4–8.5) | (5–11) |
| BA–CA (yr) | n=1,662 | n=1,071 | n=157 | n=7 | n=166 | n=261 |
| Median (range) | -1.46 (-8.83 to 4.49) | -1.71 (-8.83 to 2.71) | -0.87 (-5.75 to 2.53) | -1.69 (-4.87 to 0.3) | -1.05 (-4.67 to 2.51) | -0.98 (-5.3 to 4.49) |
| IQR | (-2.26 to -0.78) | (-2.48 to -1.03) | (-1.68 to -0.16) | (-4.22 to -0.62) | (-1.67 to -0.36) | (-1.87 to -0.26) |
Values are presented as number (%) unless otherwise indicated.
Percentages may not add up to 100%, as they are rounded to the nearest percent. Range is presented from minimum to maximum. GHD, growth hormone deficiency; TS, Turner Syndrome; CRF, chronic renal failure; SGA, small for gestational age; ISS, idiopathic short stature; SDS, standard deviation score; BMI, body mass index; IGF-I, insulin-like growth factor I; BA, bone age; CA, chronological age; IQR, interquartile range.