Table 1.
Top 20 genes that are evaluated by degree centrality, betweenness centrality, and closeness centrality in the protein–protein interaction (PPI) networks of differentially expressed genes (DEGs) in primitive neuroectodermal tumor (PNET) vs fetal brain and PNET vs adult brain
| PNET_fetal PPI
|
PNET_adult PPI
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Node | Degree | Node | Betweenness | Node | Closeness | Node | Degree | Node | Betweenness | Node | Closeness |
| CDK1 | 27 | CDK1 | 4,313.587 | CDK1 | 0.012720965 | CDK1 | 41 | CDK1 | 23,095.275 | CDK1 | 0.013076332 |
| CDC20 | 18 | PRKCE | 2,652 | PRKCE | 0.012695796 | AURKB | 26 | ITPR1 | 10,905.288 | AURKB | 0.013039162 |
| ADCY2 | 17 | CCND1 | 1,165.1238 | CDC20 | 0.012673854 | CDC20 | 24 | AURKB | 10,013.74 | ITPR1 | 0.013028582 |
| ADCY8 | 15 | ADCY2 | 1,122.6337 | MAD2L1 | 0.012669683 | ACTN2 | 24 | PRKCE | 9,054.063 | E2F2 | 0.013016845 |
| MAD2L1 | 14 | RAC3 | 1,011 | AURKA | 0.012667599 | MYH6 | 21 | DES | 8,410.37 | CDC20 | 0.013011571 |
| AURKA | 14 | ADCY8 | 890.69086 | ADCY2 | 0.012666557 | MYL2 | 20 | ACTN2 | 7,337.6235 | MAD2L1 | 0.013008642 |
| BUB1B | 13 | ADCY1 | 571.8458 | BUB1B | 0.012666557 | MYL3 | 20 | GNAO1 | 5,398.913 | BUB1B | 0.013008642 |
| NPY | 13 | AURKA | 488.86804 | BUB1 | 0.012665515 | MYL1 | 20 | ADCY2 | 5,356.561 | BUB1 | 0.013007471 |
| BUB1 | 12 | CDC20 | 411.6197 | ADCY8 | 0.012664474 | BUB1B | 19 | EPB41L1 | 5,031.298 | KNTC1 | 0.013006301 |
| SST | 12 | CENPN | 300 | KNTC1 | 0.012662391 | TPM1 | 19 | MEF2C | 4,825.066 | UBE2C | 0.013002205 |
| SSTR1 | 12 | VIP | 286.2789 | CCND1 | 0.01266135 | MAD2L1 | 19 | CAMK2B | 4,389.806 | CDK2 | 0.01300045 |
| ADCY1 | 12 | MAD2L1 | 239.80699 | ADCY1 | 0.01266135 | TPM2 | 19 | CXCR4 | 4,049.0935 | CCNB2 | 0.012998696 |
| CENPE | 11 | CCK | 213.20595 | KIF11 | 0.01266135 | NEB | 19 | ADCY1 | 3,888.9302 | PRKCE | 0.012998111 |
| NDC80 | 11 | BUB1 | 204.821 | UBE2C | 0.012660309 | TCAP | 19 | E2F2 | 3,759.39 | CDCA8 | 0.012997527 |
| GRM3 | 11 | SST | 186.63498 | CCNB2 | 0.012658228 | BUB1 | 18 | ALDOA | 3,735 | EZH2 | 0.012994604 |
| CNR1 | 11 | PRC1 | 169.05087 | PTTG1 | 0.012657188 | TNNC2 | 17 | DNM1 | 3,382.4194 | KIF11 | 0.0129911 |
| GRM2 | 11 | BUB1B | 159.02266 | CDK6 | 0.012655107 | TNNT3 | 17 | CACNG3 | 2,917 | PTTG1 | 0.012989348 |
| CAMK2B | 10 | GRM1 | 158.53731 | CCNA2 | 0.012655107 | CDK2 | 17 | HDAC2 | 2,731.5586 | DES | 0.012988764 |
| CENPN | 10 | CAMK2B | 156 | PRC1 | 0.012654067 | CENPE | 17 | HSPA2 | 2,550.4004 | CCNA2 | 0.012987597 |
| CENPF | 9 | NPY | 154.90135 | FBXO5 | 0.012651988 | TNNI2 | 17 | STXBP1 | 2,508 | SMC4 | 0.012987597 |