Table 4.
Differentially expressed microRNAs in HCC and their targets
| miRNA | Adj P-value | LogFC | Target gene (number of total target genes) |
|---|---|---|---|
| hsa-miR-550 | 0.353507 | 2.45675 | TMEM47 TIA1 EDA2R TXNDC13 CROT HCN1 FGF12 KIAA1627 (236) |
| hsa-miR-1 | 0.31072 | 2.39629 | CLCN3 DDX5 ANKRD29 PFTK1 POGK H3F3B BDNF ARHGEF18 (526) |
| hsa-miR-378* | 0.032305 | 2.21661 | SUFU (1) |
| hsa-miR-494 | 0.436284 | −2.00019 | RAP1B C5 H3F3B GLIS3 ZNF207 DCP2 CHD9 ZFX (522) |
| hsa-miR-146b-5p | 0.07674 | −2.05892 | HMBOX1 SFRS6 SYT1 SMAD4 USP3 TRAF6 CCDC117 BCORL1 (279) |
| hsa-miR-210 | 0.020936 | −2.48626 | EFNA3 FAM116A NPTX1 ISCU ACVR1B GPD1L ZNF827 TMEM20 (38) |
| hsa-miR-144 | 0.284664 | −2.53919 | BRPF1 BACH2 NPTX1 SEMA6A ATP2B1 PTGFRN PHTF2 FBXL3 (622) |
| hsa-miR-186 | 0.288715 | −3.01538 | JAG1 MITF OSBPL8 CCNT2 EIF4E PPP1CC PRKCI RAB6A (944) |
| hsa-miR-21 | 0.006681 | −3.03907 | RP2 YAP1 ADNP ARHGEF7 C17 BAHD1 KIAA1012 GLCCI1 (338) |
| hsa-miR-142-3p | 0.07674 | −3.05488 | MAP3K7IP2 C9 MMD EML4 VAMP3 TARDBP XPO1 CFL2 (242) |
| hsa-miR-29b | 0.000437 | −3.65926 | HBP1 TUBB2A TFAP2C TRIM37 SPTAN1 TET1 ZDHHC5 (737) |
| hsa-miR-222 | 0.412736 | −5.80732 | CDKN1B ARID1A VAPB POGZ CDC2L6 TMCC1 INSIG1 ZEB2 (309) |
Notes: A positive logFC value represents that the microRNA is upregulated in HCC, while a negative logFC value represents that the microRNA is downregulated in HCC.
*
has-miR-378 expression level is low.
Abbreviations: FC, fold change; HCC, hepatocellular carcinoma.