Figure 2.

Examples of unorthodox cancer-linked RBPs. Architecture of (a) RNA-binding HSP90 proteins (b) IDH proteins 1 and 2 (c) the three ERM proteins. Lollipops indicate the cancer-associated mutations available in the ICGC data portal [62], black boxes represent Pfam-annotated [63] protein domains, red and orange boxes map the high-confidence and candidate RNA-binding sites reported by RBDmap [20^••], respectively, and green boxes indicate regions which are predicted to be intrinsically disordered (IUPred score > 0.4) [64]. Frequently mutated residues in IDH1 and IDH2 proteins with established links to several cancers (see text for further information), are denoted by the number of reported mutations in parentheses.