Table 1.

Buprenorphine Blocks CFA-induced Heat Withdrawal Latencies in Submandibular Area

	CFA	CFA + BUP	P
Basal	18.1 ± 1.2	14.0 ± 1.6	.052
D1	15.8 ± 0.9	30.0*	.012
D2	15.3 ± 1.1	30.0*	.012

Data are represented at the average withdrawal latency (seconds) ± SEM. n ≥ 3 for all conditions.

^*The cutoff value used for these studies was 30 seconds. Animals that did not respond within this time were assigned a withdrawl latency value of 30.0 seconds. CFA, complete Freund’s adjuvant; BUP, buprenorphine.