Figure 1. Schematic of pancreatic cell lineages and key lineage transcription factors.

(A) Undifferentiated progenitor cell types are shown in circles. Differentiated cells are shown in other shapes. Key lineage-determining transcription factors up- or down-regulated at each stage are shown in bold. (B) Scheme of rodent islet showing insulin-producing β cells at the islet core and comprising the majority of the islet. All other endocrine cells are found at the islet periphery.