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. Author manuscript; available in PMC: 2018 Apr 11.
Published in final edited form as: Chem Rev. 2017 Jul 19;117(15):10377–10402. doi: 10.1021/acs.chemrev.7b00100

Figure 2.

Figure 2

Phage display on M13 and T7 phages. For M13 phage, the 5 copies of pIII are usually utilized in phage libraries for biopanning. After a desired targeting sequence is obtained, that sequence may be genetically engineered into another M13 phage to be displayed on the much more plentiful pVIII. Biopanning is frequently done with pIII rather than pVIII for M13 phages. For T7 phage, the capsid is composed of 415 copies of the coat protein 10A and/or 10B. Through phage display, ∼5–15 copies of the genetically engineered peptide sequence will be displayed on the C-terminus of capsid 10B.126