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. Author manuscript; available in PMC: 2018 Apr 11.
Published in final edited form as: Chem Rev. 2017 Jul 19;117(15):10377–10402. doi: 10.1021/acs.chemrev.7b00100

Figure 3.

Figure 3

Topology of the AAV2 capsid. Blue indicates position of the seven additional random amino acid residues near the distal portions of the 3-fold spikes on the AAV2 capsid surface. The inset shows a cross section through a spike region at a higher resolution with Arg588 shown in red and the adjacent seven amino acids (derived from the library insertion) shown in blue.128 Adapted with permission from ref128. Copyright 2003 Nature Publishing Group.