Table 3.

Summary of Human Cell-Targeting Peptides Derived from Virus Libraries

	organism/cell type	viral library	targeting peptide sequence	applications	ref
cancer cells	human breast carcinoma SKBR-3	f8/8 landscape//M13 phage	VSSTQDFP	SKBR-3 breast cancer cells internalization	71
	basal cell adhesion molecule (BCAM) and laminin subunit alpha 5 (LAMA5) of human colorectal cancer cells	Ph.D.-7//M13 phage	ASGLLSLTSTLY, SSSLTLKVTSALSRDG	impairs adhesion of KRAS mutant colorectal cancer cells to endothelial cells	72
	esophageal cancer cells	Ph.D.-12//M13 phage	RALAHPRDHPDL, ATCSMLLSRNEA	early screening of esophageal cancer	73
	PPC-1 human prostate carcinoma cell	T7 library//T7 phage library	(R/K)XX(R/K)	PPC-1 human prostate carcinoma cell targeting	74
	PC3 human prostate cancer cells in vitro and in vivo	Ph.D.-12//M13 phage	KQFSALPFNFYT	targeted delivery of doxorubicin to prostate cancer cells	75
	colon cancer cell line SW480	Ph.D.-7//M13 phage	VHLGYAT	imaging	76
	U87MG malignant glial cell line	Ph.D.-12//M13 phage	VTWTPQAWFQWV	drug delivery	77
	hepatocellular carcinoma cell line BEL-7402	Ph.D.-12//M13 phage	AGKGTPSLETTP	drug delivery	78
	cervical carcinoma	CX9C//M13 phage	C(R/Q)L/RT(G/N)XXG(A/V)GC	drug delivery	79
	human colorectal cell line WiDr	Ph.D.-12//M13 phage	HEWSYLAPYPWF	gene delivery	80, 81
	neuroblastoma and breast cancer cell	Ph.D.-12//M13 phage	VPWMEPAYQRFL	imaging	82, 83
	acute myeloid leukemia cells	X7 AAV2//adeno-associated virus 2	NQVGSWS	acute myeloid leukemia gene therapy	84
	HO-8910 ovarian cancer cells	Ph.D.-7//M13 phage	NPMIRRQ	potential ovarian cancer diagnosis tool	85
	human gastric adenocarcinoma cancer cells	Ph.D.-12//M13 phage	ETAPLSTMLSPY	peptide can bind to the surface of gastric adenocarcinoma cancer cells and reverse their multidrug resistance	86
			IHKDKNAPSLVP	high affinity and specificity binding to gastric adenocarcinoma cancer cells	87
	HO-8910 ovarian cancer cells; promiscuous ligand targeting of lung and pancreatic cancer cells	Ph.D.-C7C//M13 phage	SWQIGGN	control of ovarian cancer cell migration, viability, invasion, and adhesion capacity	88
		F8/9//M13 phage	GSLEEVSTL, GEFDELMTM	promiscuous ligand targeting of lung and pancreatic cancer cells for targeted doxorubicin delivery	89
stem cells	primate embryonic stem cells	Ph.D.-12//M13 phage	APWHLSSQYSRT	imaging	90
	human mesenchymal stem cells	Ph.D.-7//M13 phage	EPLQLKM	recruitment of hMSCs	91
	human pluripotent stem cell-derived progenitor cell lines	Ph.D.-12//M13 phage	EWLFEFPTPVDA, DWIATWPDAVRS	cell isolation	92
	adult neural stem cell surface receptors (one or more)	Ph.D.-7//M13 phage	KLPGWSG	enhanced neural stem cell neuronal differentiation in vitro	93
	human embryonic progenitor cell line W10	Ph.D.-12//M13 phage	DWLWSFAPNVDT	imaging	94