Table 4.

Summary of Tissue-Targeting Peptides Derived from Virus Libraries in Preclinical or Clinical Trials

	tissue type	viral library	targeting peptide sequence	applications	ref
tumor	MDA-MB-435 breast carcinoma xenografts	CX7C//T7 phage	CGNKRTRGC	MDA-MB-435 breast carcinoma xenografts targeting	95
tissues	p32-expressing breast tumors	CX7C//T7 phage	CKRGARSTC	drug delivery to p32-expressing breast tumors	96
	gastric tumor tissues	Ph.D.-12//M13 phage	AADNAKTKSFPV	imaging	97
	bladder tumor tissues	CX7C T7//T7 phage	CSNRDARRC	imaging	98
		Ph.D.-C7C//M13 phage	CSSPIGRHC	imaging	18
	vasculature of human gastric cancer	Ph.D.-C7C//M13 phage	CGNSNPKSC	imaging	99
	human lung adenocarcinoma	CX7C//M13 phage	CAKATCPAC	imaging	100
		CX7C//M13 phage	LYANSPF	imaging	101
other tissues	brown adipose tissue	mixture of cyclic CX7C and CX8C//M13 phage	CPATAERPC	imaging	102
	normal breast tissue	CX7C//T7 phage	CPGPEGAGC	breast tissue targeting	103
	ischemic stroke tissue	CX7C//phage T7	CLEVSRKNC	imaging	104
	endothelium of the pulmonary vasculature	X7AAV2//adeno-associated virus 2	ESGHGYF	gene delivery	105
	tympanic membrane transport to middle ear tissue	Ph.D-12//M13 phage	SADSTKTTHLTL	targeted transportation across the tympanic membrane to the middle ear for patients infected with otitis media	106
	brain microvasculature endothelial cell tissue	heptapeptide AAV2//adeno-associated virus 2	NRGTEWD	targeted gene-therapy vector able to ameliorate severe cerebrovascular pathology of incontinentia pigmenti	107
	central nervous system and other tissues including brain, spinal cord, muscle, pancreas, and lung tissues	AAV capsid library//adeno-associated virus 1	VDFAVNTEGVYSEPRPIGTRYLTRNL	targeted gene therapy for the central nervous system and other tissues including brain, spinal cord, muscle, pancreas, and lung tissues	108
	human bone marrow	CX7C//M13 phage	GGG, GFS, LWS, ARL, FGG, GVL, SGT	peptide motifs were isolated from a human patient in vivo to map potential targets of the vasculature system	53
	human fat tissue		EGG, LLV, LSP, EGR, FGV
	human prostate tissue		AGG, EGR, GER, GVL
	human skin		GRR, GGH, GTV, ARL, FGG, FGV, SGT