Figure 2. Relationships among Aβ₄₂, tau, and longitudinal verbal memory performance.

Two-way interaction between age at each visit and Aβ₄₂ (A) or p-tau (B) on memory performance. Figures depict that although performance generally decreases with age, those with low Aβ₄₂ (high brain amyloid) exhibit most rapid decline, whereas the association between age at each visit and memory performance does not vary by p-tau. Facets depict biomarker level by quartile (1 = lowest quartile [0%–25%], 2 = 25%–50%, 3 = 50%–75%, 4 = highest quartile [75%–100%]). Aβ₄₂ = β-amyloid 1–42; p-tau = phosphorylated tau.