Fig. 1.

Clinical response of Irgm1-deficient mice receiving dextran sodium sulfate. Male SPF wild-type (WT) and Irgm1^−/− (KO) mice were administered 3% dextran sodium sulfate (DSS) in drinking water or drinking water alone (control) for 7 days. (A) Weight loss shown as a percentage of initial weight prior to treatment. (B) Average stool consistency score. (C) Hemoccult score measuring occult fecal blood. Values are means±s.e.m.; data are combined from four separate experiments. Combined cohort sizes are as follows: n=22 WT DSS, 21 KO DSS, 11 WT control, 10 KO control. *P<0.05 (KO DSS versus WT DSS).