Fig. 2.

Intestinal inflammation in specific pathogen-free Irgm1-deficient mice receiving dextran sodium sulfate. Male specific pathogen-free (SPF) wild-type (WT) and Irgm1^−/− (KO) mice were administered 3% dextran sodium sulfate (DSS) in drinking water or drinking water alone (control) for 7 days. (A) Gross colon length. (B) Representative histological tissue sections from the colon of WT and KO mice treated with DSS (H&E stain, 4× magnification). (C) Average histologic inflammation scores from indicated segments of colon. (D) Representative histological tissue sections from the ileum of WT and KO mice treated with DSS (H&E stain, 20× magnification). (E) Average histologic inflammation scores in ileum. Results from water controls were omitted from B-D, as there was no inflammation present in these samples. Values are means±s.e.m.; data are combined from two separate experiments. Combined cohort sizes were as follows: n=14 WT DSS, 9 KO DSS, 8 WT control, 9 KO control. *P<0.01.