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. 2018 Feb 1;11(2):dmm031070. doi: 10.1242/dmm.031070

Fig. 4.

Fig. 4.

Goblet cells and intestinal epithelial proliferation in specific pathogen-free Irgm1−/− and wild-type mice. Male specific pathogen-free (SPF) wild-type (WT) and Irgm1−/− (KO) mice were administered 3% DSS in drinking water or drinking water alone (control) for 7 days. (A) Representative ileal tissue sections from DSS-treated SPF WT and KO mice (PAS, 20× magnification). (B) Representative ileal tissue sections from DSS-treated SPF WT and KO mice (Ki67 IHC, 20× magnification). (C) Number of goblet cells per crypt/villus unit, based on PAS staining. (D) Number of proliferating epithelial cells per crypt/villus unit, based on Ki67 staining. n=4-5 mice/group; error bars indicate s.e.m.