Fig. 3.

Dose-response curves and images for confirmed screening hits. (A-F) Treatment with the NMDA receptor antagonist ifenprodil (B, 5 µM), the myosin inhibitor blebbistatin (C, 5 µM), the smooth muscle relaxant alverine citrate (D, 5 µM), or the long chain fatty acid pentadecanoic acid (E, 5 µM) all increased measures of neurite growth compared to DMSO treated controls (A), whereas the plant-derived natural diterpene triptolide (F, 1 µM) reduces neurite outgrowth without affecting cell number. Scale bar: 50 µm. Data are mean±s.d., n=6 wells (mean, 244 cells/well).