Table 2. Performance of three definitions of cognitive impairment in a simulated population with a 10% prevalence of cognitive impairment.

Criteria	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)	Accuracy (95% CI)
Frascati	98.7% (94.7–100%)	73.5% (69.0–78.0%)	29.4% (22.2–36.8%)	99.8% (99.1–100%)	76.1% (72.1–80.0%)
Global deficit score	98.2% (93.3–100%)	78.7% (74.4–82.7%)	33.9% (25.6–42.3%)	99.7% (99.0–100%)	80.6% (76.6–84.5%)
Mahalanobis distance	77.4% (64.5–89.4%)	94.5% (92.8–95.2%)	61.2% (48.3–74.2)	97.4% (95.7–98.8%)	92.8% (90.3–95.2%)
Combination of all three	77.4% (64.5–89.5%)	95.4% (93.2–97.3%)	65.2% (51.6–78.4%)	97.4% (95.7–98.8%)	93.6% (91.0–95.9%)