Table 1. Effects of fasudil on blood biochemistry and body weight, systolic blood pressures, heart rate in normal rats.
| Variables | Control group | Fasudil group |
|---|---|---|
| Initial BW (g) | 200.81 ± 3.95 | 206.04 ± 4.67 |
| Final BW (g) | 237.67 ± 3.92 | 244.51 ± 4.81 |
| Serum GLU (mmol/L) | 6.46 ± 0.48 | 5.86 ± 0.35 |
| Serum TC (mmol/L) | 1.34 ± 0.05 | 1.37 ± 0.04 |
| Serum TG (mmol/L) | 0.55 ± 0.04 | 0.47 ± 0.03 |
| Serum LDL (mmol/L) | 1.09 ± 0.13 | 1.01 ± 0.11 |
| Serum HDL (mmol/L) | 0.62 ± 0.01 | 0.63 ± 0.02 |
| Serum ALT (U/L) | 37.03 ± 2.74 | 37.71 ± 2.25 |
| Serum AST (U/L) | 94.67 ± 3.88 | 93.98 ± 4.23 |
| Serum CREA (μmol/L) | 42.67 ± 3.22 | 38.68 ± 2.21 |
| SBP (mmHg) | 124.33 ± 4.94 | 123.33 ± 4.82 |
| HR (bpm) | 356.33 ± 19.37 | 356.17 ± 21.51 |
Control group: rats received normal saline solution; Fasudil group: rats received fasudil (8 mg/kg/day). BW: body weight. TC: total cholesterol. TG: triglyceride. LDL: low-density lipoprotein. HDL: high-density lipoprotein. ALT: alanine transferase. AST: aspartate transferase. CREA: creatinine. SBP: systolic blood pressures. HR: heart rate. Data were expressed as the mean ± SE (n = 6 in each group).