Table 3. Incidence and relative reduction of preventable ADR for top 5 most frequently observed diagnoses.
| ICD-10 | Description | No. of incidence | Relative reductionb | ||
|---|---|---|---|---|---|
| (incidence ratesa) | (95% CI) | ||||
| Pre-DUR | Post-DUR | ||||
| (year 2010) | (year 2014) | ||||
| First-time pADRs | K71 | Drug-induced idiosyncratic liver disease | 51,349 (10.5) | 39,508 (7.9) | -25.2 (-26.7;-23.7) |
| L279 | Dermatitis due to unspecified substances taken internally | 19,463 (4.0) | 13,644 (2.7) | -31.9 (-33.0;-30.7) | |
| L278 | Dermatitis due to other substances taken internally | 10,178 (2.1) | 9,325 (1.9) | -10.9 (-12.0;-9.9) | |
| T42 | Poisoning by antiepileptic, sedative-hypnotic and antiparkinsonism drugs | 6,330 (1.3) | 5,669 (1.1) | -13.0 (-13.9;-12.0) | |
| T50 | Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances | 5,409 (1.1) | 5,590 (1.1) | 0.5 (-0.4;1.3) | |
| Repeat pADRs | K71 | Drug-induced idiosyncratic liver disease | 5,796 (1.2) | 4,794 (1.0) | -19.6 (-20.5;-18.7) |
| L279 | Dermatitis due to unspecified substances taken internally | 1,716 (0.4) | 606 (0.1) | -65.7 (-66.3;-65.1) | |
| G253 | Drug-induced myoclonus | 911 (0.2) | 541 (0.1) | -42.3 (-42.8;-41.7) | |
| D70 | Drug-induced neutropenia | 432 (0.1) | 817 (0.2) | 83.8 (83.3;84.3) | |
| E242 | Drug-induced Cushing’s syndrome | 415 (0.1) | 382 (0.1) | -10.5 (-11.0;-10.0) | |
Abbreviations: pADR, preventable adverse drug reaction; CI, confidence interval; DUR, drug utilization review; ICD, International Classification of Diseases.
aNumber of incidents divided by total population in 2010 or 2014. Units: events per 10,000 population
bUnits: %