Localization of KV2.1, KV2.2, and KV8.2 in human, macaque, and mouse retina. Confocal z projections showing immunolocalization of KV2.1, KV2.2long, and KV8.2 in human (A–C), macaque (D–F), and mouse (G–I) retina. In human and macaque retina, strong expression of all channel subunits is evident at the level of the photoreceptor inner segments (IS), but the photoreceptor nuclei and terminals show absent or scant labeling. A, B, Intentionally saturated to show the presence of Kv subunits in the inner retina. ONL, Outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. B, Arrow indicates clustered membrane labeling in a ganglion cell. Scale bar, 20 μm.