Table 2.
Univariate Analysis of Neonatal Clinical Data Comparing Pregnancies in Which the Neonate Was Diagnosed With Perinatal Arterial Ischemic Stroke With Those Treated With Whole-Body Hypothermia for Hypoxic–Ischemic Encephalopathy With Abnormal Brain Magnetic Resonance Imaging
| Arterial Ischemic Stroke (n=22) | Hypoxic–Ischemic Encephalopathy (n=47) | P | |
|---|---|---|---|
| Gestational age (wk) | 39.7±0.8 | 38.9±1.6 | .03* |
| Birth weight (g) | 3,666±414 | 3,292±626 | .01* |
| Male sex | 16 (72.7) | 29 (61.7) | .37 |
| 1-min Apgar score less than 7 | 12 (54.5) | 46 (97.9) | <.001* |
| 5-min Apgar score less than 7 | 7 (31.8) | 41 (87.2) | <.001* |
| Umbilical artery pH | 7.15±0.19 (n=13) | 6.93±0.19 (n=40) | <.001* |
| Umbilical artery BD (mM) | 8.7±9.0 (n=11) | 14.9±8.5 (n=36) | .04* |
| Cord gas with pH less than 7.0 or BD greater than 12 mM | 2/13 (15.4) | 31/40 (77.5) | <.001* |
| Neonatal length of stay (d) | 10.7±7.5 | 24.6±17.7 | <.001* |
| Intraventricular hemorrhage | 1 (4.5) | 4 (8.5) | 1.0 |
| Periventricular white matter injury | 5 (22.7) | 7 (14.9) | .50 |
| Seizures | 18 (81.8) | 22 (46.8) | .008* |
| Positive blood culture | 0 | 2 (4.5) | 1.0 |
| Positive cerebrospinal fluid culture | 1 (4.5) | 0 | .32 |
| Initial neonatal WBC count (k/mm3) | 17.9±7.4 | 20.0±9.2 | .37 |
| Initial neonatal hematocrit (%) | 45.0±5.2 | 43.8±10.5 | .64 |
| Initial neonatal platelet count (k/mm3) | 215±76 | 153±62 | .001* |
| Initial neonatal serum glucose (mg/dL) | 75±24 | 104±84 | .14 |
| Initial nucleated RBCs (no./100 WBC) 50%; 5–95% | 110; 0–10,020 | 2,510; 220–34,688 | <.001* |
| Initial neonatal arterial pH | 7.30±0.18 | 7.10±0.18 | <.001* |
| Initial neonatal arterial BD (mM) | 6.3±9.4 | 17.1±8.1 | <.001* |
BD, base deficit; WBC, white blood cells; RBCs, red blood cells.
Data are mean±standard deviation or n (%) unless otherwise specified.
*
P<.05.