Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The microprocessor complex. (a) Domain structures of the human microprocessor constituents Drosha and DGCR8. Regions rich in proline, arginine and serine, or tryptophan are labeled. (b) The crystal structure of the DGCR8 core (protein data bank (PDB) ID: 2YT4). Models of dsRNA are oriented based on typical dsRBD binding and show that the DGCR8 core cannot use both dsRBDs to bind a single pre-miRNA unless extensive deformation of the helix occurs.
