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. 2018 Apr 11;13(4):e0189464. doi: 10.1371/journal.pone.0189464

Fig 7. NBCe1 protein expression regulation by D1-like (D1R and D5R) dopamine receptor agonist in hRPTCs carrying wild-type (WT) SLC4A5.

Fig 7

NBCe1 protein expression is decreased following an increase in intracellular sodium (↑Na+) (10 μmol monensin/L, 24 h) (N = 4, *P<0.001 vs VEH, one-way ANOVA, Tukey’s test) in WT SLC4A5 hRPTC. The combination of monensin (↑Na+) and D1R/D5R agonist SKF38393 (SKF, 10 μmol/L, 24 h) further decreases NBCe1 protein (N = 4, **P<0.05 vs monensin (↑Na+), #P<0.001 vs SKF, one-way ANOVA, Tukey’s test) that is blocked by the D1-like receptor antagonist LE300 (10 μmol/l, 24 h), which by itself has no effect. NBCe1 protein is not affected by SKF or LE300 in the absence of monensin.