Table 4.
Regression results using connectivity for seeds ROIs and depression group
| Seed ROI | Cluster location | MNI coordinates (x, y, z) | Cluster size (voxels) | t Value |
Average connectivitya NoDep (n = 28) |
Average connectivity PastDep (n = 13) |
Average connectivity CurrentDep (n = 33) |
|---|---|---|---|---|---|---|---|
| pgACC | R. postcentral gyrus extending to SMAb | 14, −50, 65 | 1,065 | 4.92 | 0.09 (1.9) | 0.58 (2.5) | 2.76 (2.3)* |
| L. middle frontal gyrus extending to dlPFCb | −53, 22, 34 | 469 | 4.82 | −0.76 (2.2) | −0.27 (2.8) | 2.18 (2.8)* | |
| R. postcentral gyrus | 66, −20, 41 | 443 | 4.60 | 0.10 (2.2) | −0.68 (2.9) | 2.86 (2.5)* | |
| L. superior temporal gyrus (BA 22) | −61, −6, 0 | 153 | 4.77 | 0.60 (3.1) | 0.90 (3.3) | 3.89 (3.1)* |
All regression results were significant after controlling for age (p FWE = .05, uncorrected p = .001).
a
Average connectivity scores correspond to z‐scores; means and standard deviations are reported for each depression group.
b
SMA = supplementary motor area, dlPFC = dorsolateral prefrontal cortex.
*The CurrentDep group had significantly greater connectivity than both the PastDep and NoDep groups (each p < .05).