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. 2018 Jan 25;37(15):1991–2007. doi: 10.1038/s41388-017-0081-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 8 — miR-486-5p inhibition reduces in vivo tumor growth. a qRT-PCR expression of miR-486-5p in Rh30 and Rh41 cells 48 h following transduction with miRZip-Scr or miRZip-486-5p. b Cell Titer Glo cell viability assay in cells as in (a). Subcutaneous tumor growth in Rh41 cells (c) and Rh30 cells (d) transduced with miRZip-Scr or miRZip-486-5p (n = 10 mice per group). e qRT-PCR expression of miR-486-5p in resulting Rh30 xenografts from (c) (P = 0.227). f Whole-mount brightfield and GFP imaging of Rh30 xenografts. Scale bar, 4 mm. g H&E staining and IHC staining for MYOGENIN, Ki67, and GFP/DAPI in Rh30 xenografts. Scale bar 50 μm. *P < 0.05, **P < 0.01, ***P < 0.001 for miRZip-Scr vs miRZip-486-5p