Table 1.
Mendelian Randomization analyses of cardiovascular risk factors and QRS traits.
| Risk factor | QRS trait | P-value IVW | β (SE) | P-value Weighted median | β (SE) | MR Egger intercept | P-value | Heterogeneity P-value |
|---|---|---|---|---|---|---|---|---|
| SBP | QRS duration | 1.60 × 10−2 | ||||||
| Sokolow-Lyon | 1.73 × 10 −10 | 15.21 (2.38) | 2.59 × 10 −9 | 13.69 (2.28) | 0.44 (4.05) | 0.914 | 1.74 × 10−13 | |
| Cornell | 1.20 × 10 −12 | 9.77 (1.38) | 8.56 × 10 −10 | 9.01 (1.47) | 0.30 (2.34) | 0.900 | 3.97 × 10−5 | |
| 12-lead sum | 3.99 × 10 −12 | 86.35 (12.45) | 6.69 × 10 −14 | 89.02 (11.88) | −5.15 (21.19) | 0.809 | 1.95 × 10−13 | |
| DBP | QRS duration | 4.33 × 10−2 | ||||||
| Sokolow-Lyon | 6.96 × 10 −10 | 23.20 (3.76) | 2.19 × 10 −12 | 26.26 (3.74) | 1.08 (4.28) | 0.801 | 1.82 × 10−11 | |
| Cornell | 3.08 × 10 −16 | 14.89 (1.82) | 1.93 × 10 −10 | 15.50 (2.43) | −4.38 (1.99) | 0.032 | 1.07 × 10−1 | |
| 12-lead sum | 3.28 × 10 −9 | 111.28 (18.81) | 1.78 × 10 −10 | 121.89 (19.11) | −15.52 (21.31) | 0.470 | 1.61 × 10−9 |
β = beta (in millimeters·milliseconds); DBP = Diastolic Blood Pressure; SBP = Systolic Blood Pressure; SE = Standard Error.