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. 2018 Apr 11;8:5833. doi: 10.1038/s41598-018-24226-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Positive mean diffusivity correlates of the sleep duration (hours). (a) The results shown were obtained using a threshold of threshold-free cluster enhancement (TFCE) of P < 0.05, based on 5000 permutations. The results were corrected at the whole brain level. Regions with significant correlations are overlaid on a “single subject” T1 image of SPM8. The color represents the strength of the TFCE value. Significant positive correlations with MD were observed in extensive gray and white matter regions that were mainly focused in the PFC, basal ganglia architecture, and anterior part of the corpus callosum. (b) A scatter plot with a trend line depicting correlations between mean MD in the largest significant cluster and hours of sleep duration. 95% confidence intervals for the trend lines are also shown.