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. 2018 Apr 5;9:348. doi: 10.3389/fphys.2018.00348

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Copyright © 2018 Gu, Liu, Li, Xie, Yao, Zhu, Xu, Dai, Zhong, Zhu, Ding and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of miR-21 partially rescue the inhibition of OGD/R-induced NRCM apoptosis by human serum extracellular vesicles. (A) qRT-PCRs for expression of miR-21 in supernatant and EVs extracted from mouse serum. n = 4. (B) Terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) assay for apoptosis in NRCMs (n = 4). Scale bar: 100 μm. (C) Analysis for percentage of TUNEL positive cells (n = 4). (D–F) Western blot for Bax, Bcl-2, Caspase 3, and Cleaved caspase 3, and quantitative analysis for Bax/Bcl-2 and Cleaved caspase 3/Caspase 3 ratio. β-actin was used as a loading control (n = 6). *P < 0.05; **P < 0.01; ***P < 0.001. EVs, extracellular vesicles.