Table 3.
Polysomnographic parameters measured after the administration of CBD and placebo.
| Parameter | Placebo | CBD | F value | Z value | p value |
|---|---|---|---|---|---|
| TST (min) | 389.3 (66.2) | 388.1 (51.4) | - | 0.14 | NS |
| Sleep onset latency (min) | 13.4 (12.8) | 9.8 (8.4) | - | 1.32 | NS |
| REM onset latency (min) | 138.1 (72.7) | 121.3 (62.2) | - | 0.97 | NS |
| Wake after sleep onset (min) | 46.2 (41.8) | 47.10 (41.2) | - | 0.13 | NS |
| Wake after sleep onset index (h) | 18.62 (8.47) | 24.7 (33.4) | 0.004 | - | NS |
| Apnea index (h) | 0.31 (1.3) | 0.03 (0.1) | 0.95 | - | NS |
| Hypopnea index (h) | 2.2 (3.7) | 1.8 (1.7) | 0.32 | - | NS |
| RDI (h) | 2.8 (4.5) | 2.2 (2.0) | - | 0.30 | NS |
| Sleep efficiency (%) | 85.3 (13.2) | 87.1 (10.2) | - | 0.96 | NS |
| Stage 1 sleep (%) | 4.9 (2.1) | 5.1 (3.4) | - | 0.20 | NS |
| Stage 2 sleep (%) | 45.3 (8.4) | 45.3 (8.4) | - | 0.08 | NS |
| Stage 3 sleep (%) | 31.7 (11.1) | 31.7 (11.6) | - | 0.39 | NS |
| REM (%) | 17.6 (4.1) | 16.6 (4.4) | 0.008 | - | NS |
| Lowest saturation (%) | 84.53 (14.4) | 90.03 (4.7) | - | 1.09 | NS |
| Baseline saturation (%) | 96. (1.05) | 96.65 (1.05) | 1.805 | - | NS |
CBD = cannabidiol; REM = rapid eye movement sleep; RDI = respiratory disturbance index; TST = total sleep time; I: number of events per hour. Results are expressed as means ± sem.