Table 1.

Tissue distribution and biological function of pancreatic aquaporins.

Type	Exocrine/endocrine pancreas	Cellular location	Biological function	References
AQP0	Not detected (mice, rats and humans)	–	–	Isokpehi et al., 2009
AQP1	Exocrine pancreas (rat and humans)	Acinar cells, intercalated ducts and capillaries	Pancreatic fluid secretion	Koyama et al., 1997; Hurley et al., 2001; Ko et al., 2002; Burghardt et al., 2003
AQP2	Not detected (rats and humans)	–	–	Hurley et al., 2001; Isokpehi et al., 2009
AQP3	Exocrine pancreas (humans)	Acinar and collecting duct cells	Marker of tumor aggressiveness in pancreatic ductal adenocarcinomas	Ishibashi et al., 1995; Burghardt et al., 2003; Direito et al., 2017
AQP4	Negligible expression (rat and humans)	–	–	Koyama et al., 1997; Hurley et al., 2001; Burghardt et al., 2003
AQP5	Exocrine pancreas (humans)	Intercalated and intralobular ductal cells	Pancreatic fluid secretion and marker of tumor differentiation in pancreatic ductal adenocarcinomas	Burghardt et al., 2003; Direito et al., 2017
AQP6	Not detected (mice, rats and humans)	–	–	Isokpehi et al., 2009
AQP7	Endocrine pancreas (mice and rats)	β- and δ-cells	Control of insulin synthesis and secretion, triacylglycerol accumulation and proliferation of β-cells	Matsumura et al., 2007; Best et al., 2009; Méndez-Giménez et al., 2017
AQP8	Exocrine pancreas (rat and humans)	Acinar cells	Pancreatic fluid secretion	Koyama et al., 1997; Calamita et al., 2001; Hurley et al., 2001; Burghardt et al., 2003
AQP9	Not detected (rats and humans)	–	–	Isokpehi et al., 2009
AQP10	Not detected (humans)	–	–	Hatakeyama et al., 2001; Méndez-Giménez et al., 2017
AQP11	Negligible expression (humans)	–	–	Isokpehi et al., 2009
AQP12	Exocrine and endocrine pancreas (rats)	Acinar cells and β-cells	Maturation and exocytosis of zymogen granules, marker of pancreatic damage in acute pancreatitis and pancreatic steatosis	Itoh et al., 2005; Ohta et al., 2009; Méndez-Giménez et al., 2017

AQP, aquaporin.