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. 2018 Apr 11;9:1393. doi: 10.1038/s41467-018-03764-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Mice with genetic Ccr2 deficiency are protected from PNAC. a Peripheral serum aspartate-aminotransferase (AST), alanine-aminotransferase (ALT), and total bile acid concentrations in completely unmanipulated mice (chow), DSS-pretreated mice without any further manipulation, (DSS/chow) wild-type (WT) DSS-pretreated mice infused with PN (DSS/PN), PN infused wild-type mice without DSS pretreatment (PN only), and Ccr2^−/− DSS-pretreated mice infused with PN (Ccr2^−/− DSS/PN). b Liver mRNA from the same groups of mice as in a of genes encoding BSEP (Abcb11), MRP2 (Abcc2), and FXR (Nr1h4) and c liver mRNA from DSS/PN WT and Ccr2^−/− mice of genes encoding CD11b (Itgam), Ly6C, CCR2, and F4/80 (Emr1). d Representative liver immunohistochemistry for F4/80 from chow, DSS/chow, and DSS/PN mice (black arrows point to F4/80⁺ cells). *p < 0.05 vs. all other groups by one-way ANOVA and Tukey's correction (a and c). *p < 0.05 vs. chow, PN only, Ccr2^−/− DSS/PN; ^#p < 0.05 vs. chow by one-way ANOVA and Tukey's correction (b). Data are depicted from individual mice for serum analysis and means from PCR triplicates from individual mice for gene expression data±SEM