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. 2018 Apr 5;11:105. doi: 10.3389/fnmol.2018.00105

Figure 1.

Figure 1

Domain structure of Synaptic adhesion-like molecules (SALMs) and LAR-RPTPs. (A) Domain structure of SALMs 1–5. Note that the PDZ domain-binding motif (PDZ-BD) is present in SALMs 1–3 but not in SALM4 or SALM5. FNIII, fibronectin III domain; Ig, immunoglobulin domain; LRR, leucine-rich repeats; NT and CT, N-terminal and C-terminal LRR. Note that the number of LRRs in this diagram is seven, although it was suggested to be six in early studies based on amino acid sequence analyses (Ko et al., 2006; Morimura et al., 2006; Wang et al., 2006; Nam et al., 2011). Recent X-ray crystallographic studies have identified seven LRRs in SALM5 (Lin et al., 2018) and eight LRRs in SALM2 and SALM5 (Goto-Ito et al., 2018), which may reflect different ways of defining LRRs. (B) Domain structure of LAR-RPTPs (LAR, PTPσ and PTPδ). D1 and D2, membrane-proximal and -distal tyrosine phosphatase domains of LAR-RPTPs; meA/B/C; mini-exon A/B/C.