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Exosome remodeling by EBV. EBV enters in the cell via the recognition of gp350 by the CD21 receptor. EBV-infected cells produce exosomes enriched for LMP1, gp350, and EGFR. Alongside cellular RNAs, these exosomes also contain viral RNAs, miRNAs, and proteins. Following the release of these EBV-modified exosomes, they can enter uninfected cells where their cargo can be incorporated into the recipient cell and start their mechanism of action.
