Table 4.

Influence of csDMARD, bDMARD, or prostaglandin medication on the expression of cytokines in the anterior chamber.

	csDMARD			bDMARD			Prostaglandins
	Neg	Pos	P-value	Neg	Pos	P-value	Neg	Pos	P-value
Number	4	26		25	5		9	6
IL-8	4.2 ± 3.2	7.1 ± 9.5	0.56	7.3 ± 9.6	3.3 ± 2.7	0.37	7.4 ± 12.7	4.7 ± 2.3	0.61
MCP-1	110.1 ± 35.5	160 ± 100	0.33	158 ± 97	130 ± 91	0.56	141 ± 72	151 ± 65	0.79
MMP-1	11.2 ± 8.5	196 ± 807	0.65	38.4 ± 58.9	838.45	0.027	12.7 ± 6.3	30.7 ± 41.3	0.21
MMP-2	821 ± 363	984 ± 380	0.42	1,014 ± 376	704 ± 280	0.09	1,099 ± 428	875 ± 192	0.2567
MMP-3	6,211 ± 4,074	7,924 ± 4,526	0.48	8,210 ± 4,525	5,124 ± 3,200	0.16	7,779 ± 3,522	8,574 ± 3,794	0.68
MMP-9	2.3 ± 2.1	5.5 ± 5.3	0.25	5.5 ± 5.3	2.8 ± 3	0.28	4.1 ± 3.9	2.9 ± 1.9	0.54
SAA	2,074 ± 2,034	7,166 ± 7,433	0.18	6,648 ± 7,002	5,686 ± 8,705	0.78	3,708 ± 4,723	2,663 ± 2,240	0.62
TGFβ-1	311 ± 250	1,844 ± 2,053	0.15	1,213 ± 1,261	3,775 ± 3,471	0.0059	1,026 ± 8,48	1,511 ± 1,087	0.35
TGFβ-2	1,188 ± 1,243	2,643 ± 1,877	0.14	2,448 ± 1,987	2,456 ± 1,147	0.99	3,047 ± 1,751	4,180 ± 1,074	0.18
TGFβ-3	76 ± 32	289 ± 291	0.16	252 ± 299	301 ± 171	0.73	195 ± 244	201 ± 154	0.96
TNF-α	19 ± 32	22 ± 32	0.87	25 ± 33	5.3 ± 3.2	0.2	28 ± 41	21 ± 24	0.71

Mean values for cytokine concentrations of eyes are depicted without or with systemic or topical treatment, csDMARD, and bDMARD for all eyes with JIAUwG and prostaglandins. Differences in cytokine expression with or without medications were calculated by Student’s t-test.

IL-8, interleukin-8; MCP-1, monocyte chemoattractant protein-1; SSA, serum amyloid A; TGFβ-1, transforming growth factor beta-1; TNF-α, tumor necrosis factor-alpha.