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. 2018 Apr 5;9:305. doi: 10.3389/fphar.2018.00305

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Copyright © 2018 Del Tredici, Malhotra, Dedek, Espin, Roach, Zhu, Voland and Moreno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional categories of structural variants. Frequency of alleles which include (A) 2 or more copies of normal function genes (N = 3,763), (B) ≥ two copies of decreased function variants or tandems with decreased function (n = 753), (C) gene deletions (CYP2D6 *5) or ≥ 2 copies of variants with no function (n = 9,395). Functional status is defined based on the functional category for the single gene copy. *4xN represents *4N-*4, *4N-*4xN, *4NxN, *4NxN-*4, *4NxN-*4xN, and *4xN. 36-*10 represents *36-*10, *36-*10xN, *36xN-*10, and *36xN-*10xN.