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. 2018 Apr 11;8:5842. doi: 10.1038/s41598-018-24221-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DNA methylation status of human HIF3A promoter. (a) Schematic diagram of the HIF3A promoter region, CpG islands and DNAse I hypersensitive sites (DHS) surrounding the three transcription start sites. Vertical black lines represent the three methylation sites in intron 1 in association with high BMI²⁵. (b) MS-PCR analysis of genomic DNA extracted from hMSCs exposed to different pro-inflammatory cytokines in normoxic and hypoxic conditions. The locations of PCR amplicons (#1 to #4) are shown in (a). Three independent experiments were performed and a representative experiment is reported. Images derived from different part of the same gel and cropped for layout reasons and included in Suppl. Information.