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. 2018 Apr 11;9:1390. doi: 10.1038/s41467-018-03720-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Clinical findings in melorheostosis. a Clinical appearance of Melo-10 with melorheostosis of right lower extremity. Note irregular thickening of the right leg. The affected bone was found to harbor a MAP2K1 mutation. b Radiograph of the right tibia/fibula of Melo-10 with classic candle-wax appearance. c Maximal intensity projection (MIP) ¹⁸F-NaF PET image of the lower extremities showing intensely increased ¹⁸F-NaF activity in the bones of the right leg, primarily along the medial and distal femur, and along the tibia extending into the foot. d, e Axial CT and fused ¹⁸F-NaF PET/CT images at the level of mid-calf demonstrating dense cortical bone formation in the anterior and posterior aspect of the right tibia (red arrows in d with corresponding abnormally increased ¹⁸F-NaF uptake (white arrows, in e)