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. 2018 Apr 11;8:5848. doi: 10.1038/s41598-018-24165-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DEX treatment affected IOP and outflow facility. (A) Boxplot of IOP for DEX-treated (n = 25) and vehicle-treated mice (n = 16). (B) Boxplot of outflow facility (C) for DEX-treated (n = 11) and vehicle-treated mice (n = 10). For each box, the central mark is the median, the edges of the box are the 25th and 75th percentiles, and whiskers extend to the most extreme data points not considered outliers. Each dot represents the data from one eye. (C) IOP measured on the day mice were sacrificed plotted as a function of outflow resistance (1/C) for DEX-treated (grey dots, n = 11) and vehicle-treated (white dots, n = 10) mice. The black solid line is the best fit using linear least squares regression. The gray-shaded region shows 95% confidence bounds for the regression. ***p-value < 0.001. NS.: Not Significant. Data in panels B and C are from cohort 3–5.