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. 2018 Apr 11;8:5848. doi: 10.1038/s41598-018-24165-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Regional heterogeneity of TM in DEX- (N = 12) or vehicle- (N = 5) treated mice. The outer TM (grey) was stiffer than the inner TM (white) in DEX mice (mean ± SD = 2.26 ± 1.76 kPa for outer TM and 1.14 ± 0.82 kPa for inner TM), but this difference did not reach statistical significance in vehicle mice (2.19 ± 0.55 kPa for outer TM and 1.35 ± 0.73 kPa for inner TM). For each box, the central mark is the median, the edges of the box are the 25th and 75th percentiles, and whiskers extend to the most extreme data points not considered outliers. Each dot represents the data from one animal. ***p < 0.001. NS.: Not Significant.