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. 2018 Apr 11;9:1387. doi: 10.1038/s41467-018-03748-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — β-Actin-Srf pathway induces a global reorganization of the subnuclear compartment. a Activation of the β-actin-Srf pathway alone induces a global reorganization of the subnuclear compartment that resembles partial reprogramming. Venn diagram of the chromatin-organization changes from compartment A to compartment B in NPCs. Peak numbers are shown. b A region on chromosome 13 where the patterns from A to B are similar in Actb knockout, Srf overexpression in NPCs, and reprogramming to iPSCs. c Cell-type-specific genes are enriched in genes that change their subnuclear compartment from A to B by the β-actin-Srf pathway. Asterisks and N.S. indicate a significant difference and no significant difference, respectively, between genes in the indicated group and all other genes (two-sided Fisher’s exact test; *P < 0.05)