Fig. 2.

Genome-wide signatures of P. falciparum polymorphism in Senegal and Malawi. a CSP, TRAP, and SERA2 show unusually high levels of non-synonymous nucleotide diversity. b TRAP, the TRAP amplicon region, and the CSP amplicon region have unusually high Tajima’s D values. c None of the genes or amplicon regions show strong population differentiation (F_ST). Each point represents the coding sequence from a single protein-coding gene. Solid and dashed lines mark the 95^th and 99^th percentiles, respectively. Focal genes are marked with filled symbols: CSP (circle), TRAP (square), SERA2 (triangle). Full genes are colored blue, whereas the regions selected for amplicon sequencing are colored red