Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 11;8:5803. doi: 10.1038/s41598-018-24243-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Full-length mHTT disturbed the striatal transcriptome. (a) Schematic diagram of six experimental groups in a 2 × 3 factorial design based on two genotypes (WT, TG) and three environmental conditions (SE, EE, MS) that was used to reveal effects of environmental enrichment and maternal separation on the striatal transcriptome of 2-month-old WT and BACHD rats. Gene expression (t) was modelled as a function of genotype (g), environment (e), and their interaction (g × e). (b) Composition and expression level of rat and human HTT splice variants in the striatum of 2-month-old rats with respect to genotype and environmental condition. (c) Diagram showing number of differentially expressed genes between main comparisons in the factorial design. (d) Venn diagram showing overlaps of differentially expressed genes between BACHD and WT animals in each of the tested environmental conditions. (e) Heatmap of hierarchically clustered z-scores across all experimental groups for differentially expressed genes that were identified in comparing TG_SE/WT_SE, TG_EE/WT_EE, and TG_MS/WT_MS. (f) Overrepresented Gene Ontology terms of merged differentially expressed genes in TG_SE/WT_SE, TG_EE/WT_EE, and TG_MS/WT_MS.