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. 2018 Apr 11;8:5803. doi: 10.1038/s41598-018-24243-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Shared and distinct characteristics in pathways and disease aspects for BACHD rats after environmental enrichment and maternal separation. (a) Canonical pathway analysis identified significantly enriched cellular pathways among DEGs derived in the tested environmental conditions for BACHD rats. Significance values colour-coded and hierarchically clustered representing likeliness of pathway participation. (b) Disease aspects and biological functions predicted to be affected based on DEGs derived in the tested environmental conditions. Significance values colour-coded and hierarchically clustered representing likeliness of downstream effects on disease aspects.