Table 2. Comparison of biomarkers according to TE grade.
| Variable | F0/1 (N = 129) | F2 (N = 16) | F3/4 (N = 28) | P* | ||
|---|---|---|---|---|---|---|
| F0/1 vs F2 | F0/1 vs F3/4 | F2 vs F3/4 | ||||
| ELF | 8.7 (8.2–9.2) | 9.8 (9.3–10.1) | 10.2 (9.4–11.8) | 0.0001 | < 0.0001 | 0.0831 |
| None to mild (%) | 4 (3.1) | 0 (0.0) | 0 (0.0) | 0.0010 | < 0.0001 | 0.160 |
| Moderate (%) | 112 (86.8) | 9 (56.2) | 11 (39.3) | |||
| Severe (%) | 13 (10.1) | 7 (43.7) | 17 (60.7) | |||
| M2BPGi (COI) | 0.4 (0.3–0.6) | 0.8 (0.6–1.3) | 0.9 (0.6–1.6) | < 0.0001 | < 0.0001 | 0.4494 |
| Negative (%) | 126 (97.7) | 9 (56.3) | 14 (50.0) | < 0.0001 | < 0.0001 | 0.059 |
| Positive (%) | 3 (2.3) | 7 (43.7) | 14 (50.0) | |||
| Galectin-3 (ng/mL) | 10.6 (8.5–13.2) | 11.3 (8.9–13.3) | 13.1 (10.8–16.3) | 0.3618 | 0.0036 | 0.2831 |
| sST2 (ng/mL) | 31.0 (24.0–36.4) | 37.0 (27.1–41.6) | 42.9 (33.3–74.9) | 0.1331 | < 0.0001 | 0.0192 |
Data are presented as median (interquartile range) or number (percentage).
*Mann-Whitney U test (galectin-3 and sST2); chi-square test or Fisher's exact test (ELF and M2BPGi).
Abbreviations: TE, transient elastography; ELF, enhanced liver fibrosis; M2BPGi, Mac-2-binding protein glycosylation isomer; sST2, soluble suppression of tumorigenicity 2.