Table 3. Comparison data of four carcinoembryonic antigen (CEA) immunoassays using 355 serum samples with CEA<100 ng/mL.
Statistics | Centaur XP (y) vs i2000sr (x) | Centaur XP (y) vs E170 (x) | Centaur XP (y) vs DxI800 (x) | i2000sr (y) vs E170 (x) | i2000sr (y) vs DxI800 (x) | E170 (y) vs DxI800 |
---|---|---|---|---|---|---|
Passing-Bablok regression | ||||||
Regression equation | y=−0.629+0.628x | y=−0.377+0.671x | y=−0.038+0.709x | y=0.665+1.038x | y=1.214+1.114x | y=0.557+1.045x |
Intercept (95% CI) | −0.910 to −0.386 | −0.595 to −0.181 | −0.199 to 0.104 | 0.269 to 1.048 | 0.640 to 1.727 | 0.240 to 0.904 |
Slope B (95% CI) | 0.597 to 0.657 | 0.648 to 0.693 | 0.691 to 0.729 | 0.996 to 1.074 | 1.049 to 1.175 | 1.002 to 1.085 |
Cusum test for linearity | ns (P=0.97) | ns (P=0.88) | ns (P=0.20) | ns (P=0.31) | ns (P=0.46) | ns (P=0.38) |
Bland-Altman analysis | ||||||
Mean difference (ng/mL) (95% CI) | −8.1 (−9.1 to −7.2) | −6.5 (−7.2 to −5.7) | −5.1 (−6.0 to −4.3) | 1.6 (1.1 to 2.2) | 3.0 (2.2 to 3.8) | 1.3 (0.6 to 2.1) |
P value | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 0.0003 |
Abbreviations: y, y axis; x, x axis; 95% CI, 95% confidence interval.