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. 2018 Apr 11;38(15):3840–3857. doi: 10.1523/JNEUROSCI.2031-17.2018

Figure 5.

Figure 5.

HtrA1 is differentially expressed by astrocytes in different forebrain regions. A–F″, IF images of β-gal (green), S100 β (red), and GFAP (magenta) expression in the forebrain of adult HtrA1-LacZ reporter mice (n = 3). Examination of multiple brain regions including upper (layers 1–3; A–A″) and deeper (layers 4–6; B–B″) neocortex, corpus callosum (C–C″), dentate gyrus of the hippocampus (D–D″), dorsal thalamus (E–E″), and ventral hypothalamus (F–F″) revealed varying levels of IF in multiple brain regions. G, Quantification of integrated signal density of IF for each protein in each brain region. Comparison of upper and deeper cortical layers reveals a significant difference (p = 0.003) in β-gal expression level, A.U., Arbitrary Unit. H, Quantification of the percentage of Aldh1L1-expressing cells that also express β-gal in different brain regions of adult HtrA1-LacZ reporter mice (n = 3). **p < 0.01. Scale bar, 50 μm.