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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: ACS Nano. 2016 Jul 21;10(8):7926–7933. doi: 10.1021/acsnano.6b03858

Figure 1. Optimization of neuron-targeted nanoparticles.

Figure 1

(A) Schematic of neuron-targeted nanoparticle formulation with tandem peptides and siRNA and entry into injured tissue. (B) Hydrodynamic diameter of nanoparticles formulated at various peptide:siRNA ratios. Inset: TEM image of TP-RVG particle formed at 20 peptide/siRNA ratio. Scale bar represents 100 nm. (C) Knockdown activity of nanoparticles formulated at various peptide/siRNA ratios analyzed by RT-qPCR. Error bars represent SD, One-way ANOVA *p<0.05, **p<0.01, ***p<0.001.