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. 2018 Apr 11;16:95. doi: 10.1186/s12967-018-1475-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Immunohistochemical analysis for GLUT-1 expression in resected intrahepatic cholangiocarcinoma specimens and ¹⁸F-FDG-PET/CT scans. a A tumor with wild-type KRAS showed negative staining (score 0) for GLUT-1, and ¹⁸F-FDG-PET/CT scans showed modest accumulation of ¹⁸F-FDG in the tumor (MTV, 3.6; TLG, 31.9). b A tumor with mutated KRAS showed moderate membranous staining (score 3) for GLUT-1, and ¹⁸F-FDG-PET/CT scans showed intense accumulation of ¹⁸F-FDG in the tumor (MTV, 76; TLG 213). The scale bar represents 100 μm. GLUT-1 glucose transporter-1, ¹⁸F-FDG-PET ¹⁸F-fluorodeoxyglucose positron emission tomography, MTV metabolic tumor volume, TLG total lesion glycolysis